Physiological responses to cisplatin using a mouse hypersensitivity model

Hypersensitivity and cross-reactivity to cisplatin and carboplatin.

Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergenc...

Measuring physiological responses to stressors using a novel Hmox1 reporter mouse

hypersensitivity and cross-reactivity to cisplatin and carboplatin.

abstract cisplatin was the first of the platinum drugs. second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (hsr) to carboplatin. she was admitted to the...

Physiological and Antioxidative Responses of a Halophytic Grass Leptochloa fusca L. Kunth (Kallar grass) to Salinity

The effects of salt stress on growth and some physiological parameters of halophytic plant, Leptochloa fusca L. Kunth, were investigated. The seedlings were irrigated with half-strength Hoagland solution and then treated with different concentrations of NaCl (0, 100, 300, 500 and 700 mM) for 15 days. The fresh and dry weights of both root and shoot were unchanged at 100 mM NaCl and decreased at...

Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma.

PURPOSE The aim of the present study was to evaluate the effects of piroxicam, a widely used nonsteroidal anti-inflammatory drug, alone and in combination with cisplatin (CDDP), on cell growth of mesothelioma cells. EXPERIMENTAL DESIGN Cell proliferation, cell cycle analysis, and microarray technology were done on MSTO-211H and NCI-H2452 cells treated with piroxicam. Moreover, the effects of ...